Figure 1
From: Segregation mechanisms of tissue cells: from experimental data to models
Dynamics of 2-dimensional segregation of keratocytes in culture. Left: Segregation in mixed co-cultures of primary goldfish keratocytes (PFK, red) and EPC fish keratocytes (EPC, green), consisting of >250 000 cells. Upper panel shows initial stage after cell attachment, lower panel shows final stage after 17 hours of cell migration. Scale bar is 100 μm. An additional movie file shows the dynamics of this in more detail [see Additional file 1]. Right: Average cluster diameter growth curves calculated from experiments with primary goldfish keratocytes (PFK) or human keratocytes (HaCaT). Exponent values obtained from fitting straight line segments to experimental curves are shown. Cluster growth curve of simulated segregation of cells without collective motion characterized by exponent value α = 0.33 is shown for reference (black solid line). From Mehes et al. (2012).