Figure 8
From: Segregation mechanisms of tissue cells: from experimental data to models
Segregation dynamics of simulated ectoderm and endoderm cells. Left: Cell sorting of 800 cells. The endodermic and ectodermic cells are represented by black and gray circles, respectively. (a) The initial cluster with mixed cell types. (b) The cluster after 3000 time steps and (c) is taken at t = 3×105. Clusters of endodermic cells form and grow as time passes by. (d) At t = 2 × 106 a single endodermic cluster is formed, but isolated cells remain within the ectoderm tissue, in agreement with experiments of Rieu et al. (1998). Right: Cell sorting in two dimensions from a random, roughly circular initial aggregate of N = 6400 cells in a proportion of 1:3 endodermic to ectodermic cells. Evolution of the segregation index, γ, for different α values. The dashed line has a slope -λ = - 0.18. Inset: Same in three dimensions but with α = 0.01 and β11 = 8.3. The dashed line has a slope -0.16. From Belmonte et al. (2008) with permission of Phys. Rev. Lett.