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Complex Adaptive Systems Modeling
Fig. 6 | Complex Adaptive Systems Modeling

Fig. 6

From: On the modeling and analysis of the biological regulatory network of NF-\({\kappa }\)B activation in HIV-1 infection

Fig. 6

BRN of NF-\(\kappa\)B responsible for the cytokine production and regulation. HIV stimulates NF- \(\kappa\)B and TNF-\(\alpha\) production while TNF-\(\alpha\) in turn regulates HIV and NF-\(\kappa\)B that helps HIV to replicate itself. Threshold of 2 represents that HIV wins the battle to trans-activate itself even at low expression level of NF-\(\kappa\)B immediately after entering into cellular environment while TNF-\(\alpha\) will build at later points depending upon increased or greater levels of NF-\(\kappa\)B

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